In this series so far, I've often discussed ways to get random stimulus that sparks off free association of some kind. But once you get that stimulus, the direction in which you take that design is often guided by your understanding of what you think is good in a card.
Oftentimes, I'll look at the initial stimulus and see something that connects to a design question I've been thinking about (such as "how do I make mill spells interactive and strategic?"), or a category of fun that I want to cater to, and that guides me to the final design.
When designing cards, it's important to have this sort of perspective on what you think cards should be like.